Processing of ovalbumin by cathepsin S

Stable Identifier
R-NUL-1236960
Type
Reaction [transition]
Species
Gallus gallus
Compartment
General
SVG |   | PPTX  | SBGN
Processing of ovalbumin by cathepsin S

Endocytic compartments contain many cysteine proteases such as cathepsin S that can generate cross-presented peptides. Cathepsins may participate in the generation of MHC class II-presentated peptides (Villadangos et al. 1999). Shen et al. (2004) demonstrated that cathepsin S contributes to TAP-independent cross-presentation in vivo, showing that ovalbumin was cross-presented by denritic cells (DCs) through both TAP-dependent and TAP-independent pathways. The TAP-independent pathway was sensitive to the cystine protease inhibitor leupeptin, but not to proteasome inhibitors. Further experiments with knockout mice showed that cathepsin S contributed to cross-presentation. DCs lacking cathepsin S lack the TAP-independent pathway (Khor et al. 2008, Shen et al. 2004).

Literature References
PubMed ID Title Journal Year
15308097 Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo

Shen, L, Sigal, LJ, Boes, M, Rock, KL

Immunity 2004
18572095 Toward a molecular explanation for cross-presentation of antigens to the immune system

Khor, B, Makar, RS

Transfus Med Rev 2008
Participants
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of Cathepsin S [early endosome lumen]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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