Reactome | Ras guanyl-nucleotide exchange mediated by Sos1 bound to GRB2 in complex with P-Shc1:P-Erbb2mut

Ras guanyl-nucleotide exchange mediated by Sos1 bound to GRB2 in complex with P-Shc1:P-Erbb2mut

Stable Identifier

R-NUL-1250472

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

General

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Ras guanyl-nucleotide exchange mediated by Sos1 bound to GRB2 in complex with P-Shc1:P-Erbb2mut

Sos1 bound to exogenously expressed human GRB2 in complex with phosphorylated mouse Shc1 and phosphorylated rat oncoprotein Erbb2mut catalyzes guanyl-nucleotide exchange on endogenous Ras in mouse fibroblasts (Xie et al. 1995).

Literature References

PubMed ID	Title	Journal	Year
8530511	Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/Neu Pendergast, AM, Xie, Y, Hung, MC	J Biol Chem	1995

Participants

Input

Output

Catalyst Activity

guanyl-nucleotide exchange factor activity of GRB2:Sos1:P-Shc1:P-Erbb2mut [plasma membrane]

Physical Entity

GRB2:Sos1:P-Shc1:P-Erbb2mut [plasma membrane] (Homo sapiens)

Activity

guanyl-nucleotide exchange factor activity (GO:0005085)

Orthologous Events

RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers (Homo sapiens)

Authored

Orlic-Milacic, M (2011-11-04)

Reviewed

Neckers, LM (2011-11-11)

Xu, W (2011-11-11)

Created

Orlic-Milacic, M (2011-04-21)

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