Direct recruitment of GRB2:Sos1 to P-Erbb2mut dimer

Stable Identifier
R-NUL-1250475
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Direct recruitment of GRB2:Sos1 to P-Erbb2mut dimer
Exogenously expressed human GRB2 in complex with mouse Sos1 is directly recruited to phosphorylated rat Neu onocoprotein (Erbb2 mutant isolated from rat neuroblastoma, with valine at position 661 replaced with glutamic acid) stably expressed in transformed mouse fibroblasts.
Literature References
Participants
Input
Output
Orthologous Events
GRB2:SOS1 complex binds phosphorylated EGFR:ERBB2 heterodimer (Homo sapiens)
Authored
Orlic-Milacic, M  (2011-11-04)
Reviewed
Neckers, LM  (2011-11-11)
Xu, W  (2011-11-11)
Created
Orlic-Milacic, M  (2011-04-21)
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