Cleavage of P-ERBB4jmA isoforms by Adam17

Stable Identifier
R-NUL-1251988
Type
Reaction [transition]
Species
Homo sapiens
Compartment
General
SVG |   | PPTX  | SBGN
Cleavage of P-ERBB4jmA isoforms by Adam17

Phosphorylated ligand-bound homodimers of ERBB4 JM-A isoforms, exogenously expressed in mouse fibroblasts, are cleaved by Adam17 metalloproteinase to yield ligand-bound ERBB4 extracellular domain and membrane bound ERBB4 fragment of 80 kDa (ERBB4m80) (Rio et al. 2000, Cheng et al. 2003).

Literature References
PubMed ID Title Journal Year
10744726 Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4

Rio, C, Buxbaum, JD, Peschon, JJ, Corfas, G

J Biol Chem 2000
12869563 Ectodomain cleavage of ErbB-4: characterization of the cleavage site and m80 fragment

Cheng, QC, Tikhomirov, O, Zhou, W, Carpenter, G

J Biol Chem 2003
Participants
Catalyst Activity
Catalyst Activity
Title
metalloendopeptidase activity of Adam17 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created