SREBP2:SCAP Transits to the Golgi

Stable Identifier
R-NUL-1655840
Type
Reaction [omitted]
Species
Cricetulus griseus
Compartment
Golgi membrane, endoplasmic reticulum membrane
Synonyms
SREBF2:SCAP Transits to the Golgi
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SREBP2:SCAP Transits to the Golgi
In low concentrations of cholesterol SCAP interacts with Sec24 of the CopII coat complex causing SCAP:SREBP1A/1C/2 to be transported with the CopII complex from the endoplasmic reticulum to the Golgi.
Literature References
PubMed ID Title Journal Year
12842885 Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs

Brown, MS, Rawson, RB, Goldstein, JL, Dobrosotskaya, IY

J Biol Chem 2003
Participants
Input
Output
Orthologous Events
SREBP1A,1C,2:SCAP translocates to the Golgi (Homo sapiens)
Authored
May, B  (2011-09-28)
Created
May, B  (2011-10-13)
Cite Us!