PI3P is phosphorylated to PI(3,5)P2 by Pikfyve at the early endosome membrane

Stable Identifier
R-NUL-1675886
Type
Reaction
Species
Mus musculus
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General
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PI3P is phosphorylated to PI(3,5)P2 by Pikfyve at the early endosome membrane

At the early endosome membrane, the PAS complex, consisting of mouse FYVE finger-containing phosphoinositide kinase (Pikfyve), yeast VAC14 homologue (VAC14), and polyphosphoinositide phosphatase aka SAC3 (FIG4), binds to the membrane via Pikfyve's FYVE finger (Sbrissa et al. 2002, Cao et al. 2007). The Pikfyve kinase component phosphorylates phosphatidylinositol 3-phosphate (PI3P) to phosphatidylinositol 3,5-bisphosphate PI(3,5)P2 (Sbrissa et al. 1999). The PAS complex is present in the cytosol and is recruited to the membrane (Sbrissa et al. 2007).

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Catalyst Activity
Catalyst Activity
Title
1-phosphatidylinositol-3-phosphate 5-kinase activity of Pikfyve:VAC14:FIG4 [early endosome membrane]
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Activity
Orthologous Events
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