PI3P is phosphorylated to PI(3,5)P2 by Pikfyve at the Golgi membrane

Stable Identifier
R-NUL-1675982
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
PI3P is phosphorylated to PI(3,5)P2 by Pikfyve at the Golgi membrane

At the Golgi membrane, the PAS complex, consisting of mouse FYVE finger-containing phosphoinositide kinase (Pikfyve), yeast VAC14 homologue (VAC14), and polyphosphoinositide phosphatase aka SAC3 (FIG4), binds to the membrane via Pikfyve's FYVE finger (Sbrissa et al. 2002). The Pikfyve kinase component phosphorylates phosphatidylinositol 3-phosphate (PI3P) to phosphatidylinositol 3,5-bisphosphate PI(3,5)P2 (Sbrissa et al. 1999, McEwen et al. 1999). The PAS complex is present in the cytosol and is recruited to the membrane (Sbrissa et al. 2007). VAC14 acts as a scaffolding protein via its C-terminal domain (Sbrissa et al. 2008).

Participants
Catalyst Activity
Catalyst Activity
Title
1-phosphatidylinositol-3-phosphate 5-kinase activity of Pikfyve:VAC14:FIG4 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
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Created