Reactome | ADAM17 cleaves Notch1 at S2

ADAM17 cleaves Notch1 at S2

Stable Identifier

R-NUL-2063915

Type

Reaction [transition]

Species

Mus musculus

Compartment

plasma membrane

ReviewStatus

5/5

General

SBML | | PDF

SVG | | PPTX | SBGN

By expressing membrane bound mouse Notch1 construct NdeltaE lacking amino acids 21-1703, it was shown that the cleavage at the S2 site precedes cleavage at the S3 site performed by the gamma-secretase complex. Human ADAM17 isolated from HeLa cells was found to be capable of cleaving NdeltaE at S2.

Literature References

PubMed ID	Title	Journal	Year
10882063	A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE Bessia, C, Black, RA, Roux, P, LeBail, O, Doedens, JR, Gupta, N, Brou, C, Israel, A, Logeat, F, Cumano, A	Mol Cell	2000