FBXW7 binds phosphorylated NICD1

Stable Identifier
Reaction [binding]
Homo sapiens
SVG |   | PPTX  | SBGN
FBXW7 binds phosphorylated NICD1

The E3 ubiquitin ligase FBXW7, a homologue of C. elegans sel-10, binds to Notch1 intracellular domain NICD1. This interaction was demonstrated by co-immunoprecipitation of the human recombinant FBXW7 and mouse recombinant NICD1 (Oberg et al. 2001). FBXW7 binds phosphorylated intracellular domain of Notch proteins, as shown for mouse NICD1 (Fryer et al. 2004) and mouse NICD4 (Wu et al. 2001).

Literature References
PubMed ID Title Journal Year
11585921 SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

Wu, G, Lyapina, S, Das, I, Li, J, Gurney, M, Pauley, A, Chui, I, Deshaies, RJ, Kitajewski, J

Mol Cell Biol 2001
11461910 The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog

Oberg, C, Li, J, Pauley, A, Wolf, E, Gurney, M, Lendahl, U

J Biol Chem 2001
15546612 Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover

Fryer, CJ, White, JB, Jones, KA

Mol Cell 2004
Orthologous Events