mNICD1 stimulates Hes1 transcription

Stable Identifier
R-NUL-2065278
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
General
SVG |   | PPTX  | SBGN
mNICD1 stimulates Hes1 transcription

Recombinant mouse NICD1 (mNICD1) expressed in HeLa cells (human cervical carcinoma cell line) associates with human RBPJ and, after binding to a recombinant mouse Hes1 promoter, activates transcription of a reporter gene (Jarriault et al. 1995). The deletion of RBP-J results in increased differentiation of Ngn3 cells, most likely because of decreased expression of Hes1 and other Notch targets (Apelqvist et al. 1999, Jensen et al. 2000).

Literature References
PubMed ID Title Journal Year
7566092 Signalling downstream of activated mammalian Notch

Jarriault, S, Brou, C, Logeat, F, Schroeter, EH, Kopan, R, Israel, A

Nature 1995
Participants
This event is regulated
Orthologous Events
Authored
Reviewed
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