Recombinant mouse NICD1 (mNICD1) expressed in HeLa cells (human cervical carcinoma cell line) associates with human RBPJ and, after binding to a recombinant mouse Hes1 promoter, activates transcription of a reporter gene (Jarriault et al. 1995). The deletion of RBP-J results in increased differentiation of Ngn3 cells, most likely because of decreased expression of Hes1 and other Notch targets (Apelqvist et al. 1999, Jensen et al. 2000).
Jarriault, S, Brou, C, Logeat, F, Schroeter, EH, Kopan, R, Israel, A
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