Reactome | rHes1 binds TLE

rHes1 binds TLE

Stable Identifier

R-NUL-2065510

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

General

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SVG | | PPTX | SBGN

A GST-tagged recombinant rat Hes1 protein exogenously expressed in HeLa cells co-immunoprecipitates endogenous TLE proteins. The WRPW motif of Hes1 is critical for this interaction.

Literature References

PubMed ID	Title	Journal	Year
8649374	The WRPW motif of the hairy-related basic helix-loop-helix repressor proteins acts as a 4-amino-acid transcription repression and protein-protein interaction domain Fisher, AL, Caudy, M, Ohsako, S	Mol Cell Biol	1996
8687460	Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif Grbavec, D, Stifani, S	Biochem Biophys Res Commun	1996

Participants

Input

Output

rHes1:TLE [nucleoplasm] (Homo sapiens)

Orthologous Events

HES1 binds TLE (Homo sapiens)

Authored

Orlic-Milacic, M (2011-11-14)

Egan, SE (2011-11-14)

Reviewed

Haw, R (2012-02-06)

Created

Orlic-Milacic, M (2012-01-23)

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