Proteasome mediated degradation of PAK-2p34

Stable Identifier
R-NUL-212917
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Proteasome mediated degradation of PAK-2p34
Proteolytically activated PAK-2p34, but not full-length PAK-2, is degraded rapidly by the proteasome (Jakobi et al., 2003). Here, degradation of PAK-2p34 is described as occurring in the cytosol. However, to date it is not known whether this occurs in the nucleus or in the cytoplasm.
Literature References
PubMed ID Title Journal Year
12853446 Caspase-activated PAK-2 is regulated by subcellular targeting and proteasomal degradation

Koeppel, MA, Jakobi, R, McCarthy, CC, Stringer, DK

J Biol Chem 2003
Participants
Input
Output
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Physical Entity
26S proteasome [cytosol] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Orthologous Events
Proteasome mediated degradation of PAK-2p34 (Homo sapiens)
Authored
Jakobi, R  (2008-02-05)
Reviewed
Chang, E  (2008-05-21)
Created
Matthews, L  (2008-02-15)
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