PP1CC dephosphorylates TGFBR1

Stable Identifier
R-NUL-2167872
Type
Reaction
Species
Homo sapiens
Compartment
cytoplasmic side of plasma membrane
Summation

Phosphorylated TGFBR1 is significantly dephosphorylated when incubated with Smad7, PPP1R15A (GADD34) and PP1CC, immunoprecipitated from previously transfected COS1 cells. Dephosphorylation is inhibited by addition of PP1 inhibitor I-1 (Shi et al. 2004).

Literature References
PubMed ID Title Journal Year
14718519 GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor

Shi, W, Sun, C, He, B, Xiong, W, Shi, X, Yao, D, Cao, X

J Cell Biol 2004
Participants
Input
Output
Catalyst Activity
Catalyst Activity
Title
phosphoprotein phosphatase activity of TGFB1:p-TGFBR:Smad7:GADD34:PP1CC:SARA [early endosome membrane]
Physical Entity
TGFB1:p-TGFBR:Smad7:GADD34:PP1CC:SARA [early endosome membrane]
Activity
phosphoprotein phosphatase activity (0004721)
Orthologous Events
PP1 dephosphorylates TGFBR1 (Homo sapiens)
Authored
Heldin, CH  (2006-02-02)
Moustakas, A  (2006-02-02)
Huminiecki, L  (2006-02-02)
Jassal, B  (2006-02-02)
Reviewed
Huang, T  (2012-05-14)