PP1CC dephosphorylates TGFBR1

Stable Identifier
R-NUL-2167872
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytoplasmic side of plasma membrane
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PP1CC dephosphorylates TGFBR1
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Phosphorylated TGFBR1 is significantly dephosphorylated when incubated with Smad7, PPP1R15A (GADD34) and PP1CC, immunoprecipitated from previously transfected COS1 cells. Dephosphorylation is inhibited by addition of PP1 inhibitor I-1 (Shi et al. 2004).

Literature References
PubMed ID Title Journal Year
14718519 GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor

Shi, W, Sun, C, He, B, Xiong, W, Shi, X, Yao, D, Cao, X

J Cell Biol 2004
Participants
Input
Output
Catalyst Activity
Catalyst Activity
Title
phosphoprotein phosphatase activity of TGFB1:p-TGFBR:Smad7:GADD34:PP1CC:SARA [early endosome membrane]
Physical Entity
TGFB1:p-TGFBR:Smad7:GADD34:PP1CC:SARA [early endosome membrane]
Activity
phosphoprotein phosphatase activity (0004721)
Orthologous Events
PP1 dephosphorylates TGFBR1 (Homo sapiens)
Authored
Heldin, CH  (2006-02-02)
Moustakas, A  (2006-02-02)
Huminiecki, L  (2006-02-02)
Jassal, B  (2006-02-02)
Reviewed
Huang, T  (2012-05-14)
Created
Orlic-Milacic, M  (2012-03-23)