Phosphorylated TGFBR1 is significantly dephosphorylated when incubated with Smad7, PPP1R15A (GADD34) and PP1CC, immunoprecipitated from previously transfected COS1 cells. Dephosphorylation is inhibited by addition of PP1 inhibitor I-1 (Shi et al. 2004).
Shi, X, Sun, C, Cao, X, Yao, D, He, B, Shi, W, Xiong, W
phosphoprotein phosphatase activity of TGFB1:p-TGFBR:Smad7:GADD34:PP1CC:SARA [early endosome membrane]
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