Smad7:SMURF2 binds phosphorylated TGFBR1

Stable Identifier
R-NUL-2169043
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
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PNG
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 | PPTX  | SBGN
Smad7:SMURF2 binds phosphorylated TGFBR1
Smad7 recruits SMURF2 to TGF-beta (TGFB1)-activated TGF-beta receptor complex. In this study, recombinant mouse Smad7 and recombinant human SMURF2, TGFBR2 and TGFBR1 were exogenously expressed in COS1 cells (Kavsak et al. 2000).
Literature References
PubMed ID Title Journal Year
11163210 Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

Thomsen, GH, Wrana, JL, Bonni, S, Causing, CG, Rasmussen, RK, Zhu, H, Kavsak, P

Mol Cell 2000
Participants
Input
Output
Orthologous Events
SMAD7:SMURF complex binds to phosphorylated TGFBR1 (Homo sapiens)
Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Created
Orlic-Milacic, M  (2012-03-27)
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