Uchl5 deubiquitinates TGFBR1

Stable Identifier
R-NUL-2179313
Type
Reaction
Species
Homo sapiens
Compartment
Summation

Recombinant mouse Uchl5 (Uch37) exogenously expressed in HEK293 cells deubiquitinates recombinant human TGFBR1. This stabilizes TGFBR1 and prolongs signaling by TGF-beta receptor complex. Deubiqutination of Smad7 has not been examined in this context (Wicks et al. 2005).

Literature References
Participants
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitin-specific protease activity of TGFB1:TGFBR2:Ub-p-TGFBR1:Ub-Smad7:Uchl5 [plasma membrane]
Physical Entity
Activity
Orthologous Events