Ubiquitination of SKI/SKIL by Rnf111

Stable Identifier
R-NUL-2186755
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Ubiquitination of SKI/SKIL by Rnf111
Recombinant mouse Rnf111 (Arkadia), recruited to recombinant human SKI/SKIL bound to TGF-beta-activated SMAD2/3, ubiquitinates SKI/SKIL transcriptional repressors (Levy et al. 2007, Nagano et al. 2007).
Literature References
PubMed ID Title Journal Year
17591695 Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation

Episkopou, V, Levy, L, Harkin, S, Hill, CS, Das, D, Howell, M

Mol Cell Biol 2007
17510063 Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-beta signaling

Episkopou, V, Miyazono, K, Yuki, K, Nagano, Y, Lee, KL, Imamura, T, Isogaya, K, Saitoh, M, Koinuma, D, Mavrakis, KJ, Fujii, T, Sase, H, Miyazawa, K

J Biol Chem 2007
Participants
Catalyst Activity

ubiquitin-protein transferase activity of p-2S-SMAD2/3:SMAD4:SKI/SKIL:Rnf11 [nucleoplasm]

Orthologous Events
Authored
Reviewed
Created
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