Gamma-secretase complex cleaves mNEXT2

Stable Identifier
R-NUL-2197556
Type
Reaction
Species
Homo sapiens
Compartment
Summation

By expressing mouse Notch2deltaE recombinant protein, which mimics the cleavage product of Adam10, NEXT2, in human embryonic kidney cell line HEK293, Saxena et al. demonstrated that the activity of the gamma-secretase complex was required for the release of Notch2 intracellular domain, NICD2, and the ensuing NICD2-mediated transcriptional response (Saxena et al. 2001).

Literature References
PubMed ID Title Journal Year
11518718 Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis J Biol Chem 2001
Participants
Catalyst Activity
Catalyst Activity
Title
aspartic-type endopeptidase activity of gamma-secretase complex [plasma membrane]
Physical Entity
Activity
Orthologous Events