Agrin binds Integrin alphaVbeta1 (alpha1beta1)

Stable Identifier
R-NUL-2467431
Type
Reaction
Species
Gallus gallus
Compartment
Summation

Agrin is a large (>400 kDa) multi-domain heparan sulfate proteoglycan found in basement membranes. The C-terminal portionof agrin contains four EGF repeats and three LG (G) domains homologous to those found in laminin alpha chains, neurexins and slits (Timpl et al. 2000). The LG domains bind alphaVbeta1 and another beta1-containing integrin (Martin & Sanes 1997, Burgess et al. 2002, Bezakova & Ruegg 2003)

Literature References
PubMed ID Title Journal Year
12423238 Mapping sites responsible for interactions of agrin with neurons

Burgess, RW, Dickman, DK, Nunez, L, Glass, DJ, Sanes, JR

J. Neurochem. 2002
9367446 Integrins mediate adhesion to agrin and modulate agrin signaling

Martin, PT, Sanes, JR

Development 1997
Participants
Orthologous Events
Authored
Reviewed