Collagen type II degradation by MMP14

Stable Identifier
R-NUL-2473590
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Collagen type II degradation by MMP14
The membrane-type MMP MMP14 (MT1-MMP) is a fibrillar collagenase able to degrade collagen types I, II and III (Ohuchi et al. 1997).
Literature References
PubMed ID Title Journal Year
8999957 Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules

Fujii, Y, Okada, Y, Sato, H, Imai, K, Ohuchi, E, Seiki, M

J Biol Chem 1997
Participants
Input
Output
Catalyst Activity

metalloendopeptidase activity of MMP14,TMPRSS6 [plasma membrane]

Physical Entity
MMP14,TMPRSS6 [plasma membrane] (Homo sapiens)
Activity
metalloendopeptidase activity (GO:0004222)
Orthologous Events
Collagen type II degradation by MMP14 (Homo sapiens)
Authored
Jupe, S  (2012-09-24)
Reviewed
Sorsa, T  (2012-10-08)
Created
Jupe, S  (2012-09-24)
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