Laminin-511 degradation by MMP14

Stable Identifier
R-NUL-2533890
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, extracellular region
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Laminin-511 degradation by MMP14
Laminins can be degraded by the membrane-associated metalloproteinase MMP14 (Ohuchi et al. 1997, Bair et al. 2005 Gutiérrez-Fernández et al. 2009). Cleavage of the alpha (Ohuchi et al. 1997, Bair et al. 2005) and beta chains (Udayakumar et al. 2003) by MMP14 has been demonstrated; gamma chain cleavage is considered likely as other MMPs are known to cleave this subunit.
Literature References
PubMed ID Title Journal Year
8999957 Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules

Fujii, Y, Okada, Y, Sato, H, Imai, K, Ohuchi, E, Seiki, M

J Biol Chem 1997
15967115 Membrane type 1 matrix metalloprotease cleaves laminin-10 and promotes prostate cancer cell migration

Cress, AE, Sekiguchi, K, Chen, ML, Bowden, GT, Bair, EL, Nagle, RB, McDaniel, K

Neoplasia 2005
Participants
Input
Output
Catalyst Activity

metalloendopeptidase activity of MMP14,TMPRSS6 [plasma membrane]

Physical Entity
MMP14,TMPRSS6 [plasma membrane] (Homo sapiens)
Activity
metalloendopeptidase activity (GO:0004222)
Orthologous Events
Laminin-511 degradation by MMP14 (Homo sapiens)
Authored
Jupe, S  (2012-08-08)
Reviewed
Ricard-Blum, S  (2013-08-13)
Created
Jupe, S  (2012-10-22)
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