Nid1 degradation by MMP1, 9, 12, ELANE

Stable Identifier
R-NUL-2533972
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Nid1 degradation by MMP1, 9, 12, ELANE
Nidogen-1 (entactin) is a member of the nidogen family of basement membrane glycoproteins. It interacts with several other components of basement membranes, notably it connects the collagen and laminin networks to each other (Yurchenko & Patton 2009). MMPs 3, 7 (Mayer et al. 1993), 1, 9, (Sires et al. 1993), 12 (Gronski et al. 1997), 14, 15 (d'Ortho et al. 1997), 19 (Stracke et al. 2000) and leukocyte elastase (Mayer et al. 1993) can all degrade Nidogen-1.
Literature References
PubMed ID Title Journal Year
8380588 Degradation of entactin by matrix metalloproteinases. Susceptibility to matrilysin and identification of cleavage sites

Chung, AE, Senior, RM, Broekelmann, TJ, Welgus, HG, Murphy, G, Griffin, GL, Mecham, RP, Sires, UI

J Biol Chem 1993
8223643 Sites of nidogen cleavage by proteases involved in tissue homeostasis and remodelling

Mayer, U, Murphy, G, Timpl, R, Mann, K

Eur J Biochem 1993
Participants
Catalyst Activity

serine-type endopeptidase activity of MMP1, MMP9, MMP12, ELANE [extracellular region]

Orthologous Events
Authored
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