Aggrecan degradation by ADAMTS4,ADAMTS5

Stable Identifier
R-NUL-2533988
Type
Reaction [transition]
Species
Bos taurus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Aggrecan degradation by ADAMTS4,ADAMTS5
The majority of aggrecan fragments present in synovial fluid of OA patients are cleaved at Glu392-Ala393 (numbered here according to the human UniProt sequence, these residues referred to as Glu373-Ala374 in most literature) in the IGD (Sandy et al. 1992). ADAMTS5 (aggrecanase-2, Abbaszade et al. 1999) and to a lesser extent ADAMTS4 (aggrecanase-1, Tortorella et al. 1999) are primarrily responsible (Gendron et al. 2007).
Literature References
PubMed ID Title Journal Year
12054629 ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors

Knauper, V, Murphy, G, Luque, A, Westling, J, Iruela-Arispe, ML, Sandy, JD, Rodríguez-Manzaneque, JC, Thai, SN

Biochem. Biophys. Res. Commun. 2002
17430884 Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4

Nagase, H, Gendron, C, Caterson, B, Thøgersen, IB, Hughes, C, Lim, NH, Enghild, JJ, Kashiwagi, M

J. Biol. Chem. 2007
15296936 ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage

DiBlasio-Smith, E, Dorner, AJ, Corcoran, C, Tan, XY, Zeng, W, Agostino, MJ, Flannery, CR, Georgiadis, KE, Annis-Freeman, B, LaVallie, ER, Morris, EA, Jin, M, Collins-Racie, LA, Arai, M

Matrix Biol. 2004
16507336 Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18

Morris, EA, LaVallie, ER, Corcoran, C, Collins-Racie, LA, Zeng, W, Flannery, CR

Biochim. Biophys. Acta 2006
12514189 Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1

Apte, SS, Leduc, R, Wight, TN, Evanko, S, Engle, JM, Ross, M, Jungers, KA, Longpre, JM, Somerville, RP

J. Biol. Chem. 2003
Participants
Catalyst Activity

metalloendopeptidase activity of ADAMTS4, 5, (1, 8, 9, 16, 18) [extracellular region]

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