Degradation of HSPG2 by Mmp13 and Ctss

Stable Identifier
R-NUL-2534170
Type
Reaction [transition]
Species
Homo sapiens
Compartment
General
SVG |   | PPTX  | SBGN
Degradation of HSPG2 by Mmp13 and Ctss

The GAG chains of HSPG2 bind growth factors in the ECM, and serve as co-ligands or ligand enhancers when bound to receptors. For example, HS-bound FGF was released from cultured cells by treatments with MMP3, rat MMP13, and plasmin (Whitelock et al. 1996). The core protein of HSPG2 can be cleaved by rat cathepsin S (Liuzzo et al. 1999).

Literature References
Participants
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of Mmp13, Ctss [extracellular region]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created