Reactome | Degradation of HSPG2 by Mmp13 and Ctss

Degradation of HSPG2 by Mmp13 and Ctss

Stable Identifier

R-NUL-2534170

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

General

SBML | | PDF

SVG | | PPTX | SBGN

The GAG chains of HSPG2 bind growth factors in the ECM, and serve as co-ligands or ligand enhancers when bound to receptors. For example, HS-bound FGF was released from cultured cells by treatments with MMP3, rat MMP13, and plasmin (Whitelock et al. 1996). The core protein of HSPG2 can be cleaved by rat cathepsin S (Liuzzo et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
8626565	The degradation of human endothelial cell-derived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases Underwood, PA, Murdoch, AD, Whitelock, JM, Iozzo, RV	J Biol Chem	1996

Participants

Input

HSPG2(22-4391) [extracellular region] (Homo sapiens)

Output

Catalyst Activity

serine-type endopeptidase activity of Mmp13, Ctss [extracellular region]

Physical Entity

Mmp13, Ctss [extracellular region] (Rattus norvegicus)

Activity

serine-type endopeptidase activity (GO:0004252)

Orthologous Events

HSPG2 (perlecan) degradation by MMP13, CTSS (Homo sapiens)

Authored

Jupe, S (2012-08-08)

Reviewed

Ricard-Blum, S (2013-08-13)

Created

Jupe, S (2012-10-24)

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