E-cadherin strand dimer degradation by Casp3

Stable Identifier
R-NUL-2534247
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
E-cadherin strand dimer degradation by Casp3
Caspase-3 (Steinhusen et al. 2001) and calpain-1 (Rios-Doria et al. 2003) cleave E-cadherin in its cytoplasmic part releasing an intracellular 37 kDa C-terminal fragment termed CTF3.
Literature References
PubMed ID Title Journal Year
11076937 Cleavage and shedding of E-cadherin after induction of apoptosis

Huber, O, Bommert, K, Steinhusen, U, Badock, V, Tauber, R, Weiske, J

J. Biol. Chem. 2001
12393869 The role of calpain in the proteolytic cleavage of E-cadherin in prostate and mammary epithelial cells

Day, KC, Chinnaiyan, AM, Kuefer, R, Day, ML, Rashid, MG, Rios-Doria, J, Rubin, MA

J. Biol. Chem. 2003
Participants
Input
Output
Catalyst Activity

serine-type endopeptidase activity of Caspase-3 tetramer [cytosol]

Physical Entity
Caspase-3 tetramer [cytosol] (Mus musculus)
Activity
serine-type endopeptidase activity (GO:0004252)
Orthologous Events
E-cadherin degradation by caspase-3 and calpain-1 (Homo sapiens)
Authored
Jupe, S  (2012-08-08)
Reviewed
Ricard-Blum, S  (2013-08-13)
Created
Jupe, S  (2012-10-24)
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