Reactome | Osteopontin binds Integrins alphaVbeta1, 3, 5

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Osteopontin binds Integrins alphaVbeta1, 3, 5

Stable Identifier

R-NUL-2752124

Type

Reaction

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Summation

Osteopontin (SPP1) is a highly phosphorylated sialoprotein that is a prominent component of the mineralized extracellular matrices of bones and teeth. It binds multiple integrins including alphaVbeta3, alphaVbeta1 and alphaVbeta5 (Liaw et al. 1995).

Literature References

PubMed ID	Title	Journal	Year
7532190	The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro	J. Clin. Invest.	1995

Participants

Input

Output

Osteopontin:Integrins alphaVbeta1,3,5 [plasma membrane] (Rattus norvegicus)

Orthologous Events

SPP1 (osteopontin) binds integrins alphaVbeta1, alphaVbeta3, alphaVbeta5 (Homo sapiens)