Osteopontin binds Integrins alphaVbeta1, 3, 5

Stable Identifier
R-NUL-2752124
Type
Reaction
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Summation

Osteopontin (SPP1) is a highly phosphorylated sialoprotein that is a prominent component of the mineralized extracellular matrices of bones and teeth. It binds multiple integrins including alphaVbeta3, alphaVbeta1 and alphaVbeta5 (Liaw et al. 1995).

Literature References
PubMed ID Title Journal Year
7532190 The adhesive and migratory effects of osteopontin are mediated via distinct cell surface integrins. Role of alpha v beta 3 in smooth muscle cell migration to osteopontin in vitro

Liaw, L, Skinner, MP, Raines, EW, Ross, R, Cheresh, DA, Schwartz, SM, Giachelli, CM

J. Clin. Invest. 1995
Participants
Input
Output
Orthologous Events
SPP1 (osteopontin) binds integrins alphaVbeta1, alphaVbeta3, alphaVbeta5 (Homo sapiens)
Authored
Reviewed