xTLE4 binds HDAC1

Stable Identifier
R-NUL-3299567
Type
Reaction [binding]
Species
Homo sapiens
Compartment
General
SVG |   | PPTX  | SBGN
xTLE4 binds HDAC1

When transfected into HEK293 cells, myc-tagged truncated versions of xTLE3 and 4 consisting of the Q and GP domains are able to co-immunoprecipitate FLAG-HDAC1 (Brantjes et al, 2001). Although the stoichiometry of this interaction has not been explicitly demonstrated, the TLE Q domain has been shown to be required for tetramerization and the repression activity of Groucho/TLE proteins, suggesting that a tetramer is the functional unit (Chen et al, 1998; Song et al, 2004)

Literature References
PubMed ID Title Journal Year
11266540 All Tcf HMG box transcription factors interact with Groucho-related co-repressors

Brantjes, H, Roose, J, van De Wetering, M, Clevers, HC

Nucleic Acids Res. 2001
15121853 Groucho oligomerization is required for repression in vivo

Song, H, Hasson, P, Paroush, Z, Courey, AJ

Mol. Cell. Biol. 2004
9819412 A role for Groucho tetramerization in transcriptional repression

Chen, G, Nguyen, PH, Courey, AJ

Mol. Cell. Biol. 1998
Participants
Orthologous Events
Authored
Reviewed
Created