Collagen type I binds integrin alpha1beta1, alpha2beta1, alpha10beta1

Stable Identifier
R-NUL-4084908
Type
Reaction
Species
Homo sapiens
Compartment
Summation

Integrin alpha1beta1 binds to collagen type IV and VI with higher affinity than to types I-III, whereas alpha2beta1 has a higher affinity for collagen types I-III than for type IV. Integrin alpha10beta1 binds collagen types I, IV, and VI with similar affinities (Tulla et al. 2001). Integrin alpha11beta1 binds preferentially to the fibril-forming collagen types I and II, binding to type III is weaker and collagens IV and VI are poor ligands (Zhang et al. 2003).

Participants
Orthologous Events