Recruitment and activation of Cdk5

Stable Identifier
R-NUL-421136
Type
Reaction [binding]
Species
Gallus gallus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Recruitment and activation of Cdk5
Cyclin-dependent kinase 5 (CDK5), a member of the serine/threonine kinase Cdk family, is complexed with p35 a neuron specific activator of Cdk5. The complex CDK5:p35 is required for neurite outgrowth and cortical lamination. CDK5:p35 complex is recruited to the growth cone by associating with active Fyn. FYN promotes the kinase activity of CDK5 by phosphorylating CDK5 on tyrosine residue 15. Activation of CDK5 by FYN via Tyr15 phosphorylation might facilitate suppression of RAC-PAK signaling downstream of PlexinA.
Literature References
PubMed ID Title Journal Year
12372285 Fyn and Cdk5 mediate semaphorin-3A signaling, which is involved in regulation of dendrite orientation in cerebral cortex

Nakamura, F, Taniguchi, M, Ohno, S, Uchida, Y, Nakajima, O, Kudo, Y, Sasaki, Y, Kishida, R, Yagi, T, Nakayama, T, Goshima, Y, Ohshima, T, Cheng, C

Neuron 2002
17607942 The CRMP family of proteins and their role in Sema3A signaling

Strittmatter, SM, Schmidt, EF

Adv Exp Med Biol 2007
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Orthologous Events
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