G alpha (i) inhibits adenylate cyclase

Stable Identifier
R-NUL-421821
Type
Reaction
Species
Canis familiaris
Compartment
Summation

G-proteins in the Gi class inhibit adenylate cyclase activity, decreasing the production of cAMP from ATP, which has many consequences but classically results in decreased activity of Protein Kinase A (PKA). cAMP also activates the cyclic nucleotide-gated ion channels, a process that is particularly important in olfactory cells. Experimental data for this reaction was obtained in vitro using rat G alpha (i) and dog Adenylate Cyclase.

Literature References
PubMed ID Title Journal Year
8119955 Distinct patterns of bidirectional regulation of mammalian adenylyl cyclases

Taussig, R, Tang, WJ, Hepler, JR, Gilman, AG

J Biol Chem 1994
8327893 Inhibition of adenylyl cyclase by Gi alpha

Taussig, R, I˝iguez-Lluhi, JA, Gilman, AG

Science 1993
Participants
Orthologous Events
Authored
Reviewed