G alpha (i) inhibits adenylate cyclase

Stable Identifier
R-NUL-421821
Type
Reaction
Species
Canis familiaris
Compartment
Summation

G-proteins in the Gi class inhibit adenylate cyclase activity, decreasing the production of cAMP from ATP, which has many consequences but classically results in decreased activity of Protein Kinase A (PKA). cAMP also activates the cyclic nucleotide-gated ion channels, a process that is particularly important in olfactory cells. Experimental data for this reaction was obtained in vitro using rat G alpha (i) and dog Adenylate Cyclase.

Literature References
Participants
Orthologous Events