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Dissociation of beta-2 adrenergic receptor:Gs complex
Stable Identifier
R-NUL-421961
Type
Reaction [dissociation]
Species
Oryctolagus cuniculus
Compartment
extracellular region
,
plasma membrane
ReviewStatus
5/5
General
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Level 2
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SBGN
The classical view of G-protein signalling is that the G-protein alpha subunit dissociates from the beta:gamma dimer. Activated G alpha (s) and the beta:gamma dimer then participate in separate signaling cascades. Although G protein dissociation has been contested (e.g. Bassi et al. 1996), recent in vivo experiments have demonstrated that dissociation does occur, though possibly not to completion (Lambert 2008).
Literature References
PubMed ID
Title
Journal
Year
3141418
Subunit dissociation is the mechanism for hormonal activation of the Gs protein in native membranes
Ransnäs, LA
,
Insel, PA
J Biol Chem
1988
Participants
Input
Isoprotenerol:beta-2 adrenergic receptor:G-protein G(s) (active) [plasma membrane]
(Oryctolagus cuniculus)
Output
Beta-2 adrenergic receptor [plasma membrane]
(Mus musculus)
G alpha (s):GTP [plasma membrane]
(Oryctolagus cuniculus)
G-protein beta:gamma complex [plasma membrane]
(Oryctolagus cuniculus)
ISPOL [extracellular region]
Orthologous Events
Dissociation of the Prostacyclin receptor:Gs complex (Homo sapiens)
Authored
Jupe, S (2009-05-22)
Reviewed
Kunapuli, SP (2010-06-07)
Created
Jupe, S (2009-05-22)
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