Activation of Clasp

Stable Identifier
R-NUL-428884
Type
Reaction [binding]
Species
Drosophila melanogaster
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Activation of Clasp
Human CLASP (CLASP1 or CLASP2) acts positively downstream of Drosophila Abl as part of the repellent response initiated by activation of Drosophila Robo1. Activation of CLASP results in inhibition of microtubule polymerization on the side of the growth cone receiving the repulsive signal and consequently the growth cone turns to the opposite side (Wills et al. 2002, Lee et al. 2004, Kalil and Dent 2004).
Literature References
PubMed ID Title Journal Year
15207236 The microtubule plus end tracking protein Orbit/MAST/CLASP acts downstream of the tyrosine kinase Abl in mediating axon guidance

Rusch, J, Engel, U, Lee, H, Sheard, K, Van Vactor, D, Scherrer, S

Neuron 2004
12441051 A Drosophila homolog of cyclase-associated proteins collaborates with the Abl tyrosine kinase to control midline axon pathfinding

Rusch, J, Wills, Z, Baum, B, Van Vactor, D, Bikoff, J, Perrimon, N, Emerson, M

Neuron 2002
Participants
Input
Output
Orthologous Events
Activation of CLASP (Homo sapiens)
Authored
Garapati, P V  (2008-09-05)
Reviewed
Jaworski, A  (2017-07-31)
Kidd, T  (2009-08-18)
Created
Garapati, P V  (2009-07-11)
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