Pig Syk binds human Vav1

Stable Identifier
R-NUL-437945
Type
Reaction [binding]
Species
Sus scrofa
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Pig Syk binds human Vav1
The SH2 region of Vav1 binds to Syk at a site including phosphorylated tyrosine Y348. Mutation of this residue to F abolishes binding and subsequent Vav1 phosphorylation. Vav2 has also been shown to bind Syk.
Literature References
PubMed ID Title Journal Year
8986718 Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product

Tartare-Deckert, S, Deckert, M, Altman, A, Mustelin, T, Couture, C

Immunity 1996
Participants
Input
Output
Orthologous Events
p-Y348-SYK binds VAV family (Homo sapiens)
Authored
Akkerman, JW  (2009-09-04)
Reviewed
Kunapuli, SP  (2010-06-07)
Created
Jupe, S  (2009-09-18)
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