Thrombopoietin binds the thrombopoietin receptor

Stable Identifier
R-NUL-443942
Type
Reaction [binding]
Species
Homo sapiens
Compartment
General
SVG |   | PPTX  | SBGN
Thrombopoietin binds the thrombopoietin receptor

Thrombopoietin (TPO) is a primary regulator of megakaryocytopoiesis. Binding of TPO to its receptor TPOR (c-Mpl) mediates pleiotropic effects on megakaryocyte development leading to significant increase in circulating platelet numbers. TPOR knockout mice show a marked reduction in bone marrow megakaryocytes and blood platelets. Although thrombopoietin (TPO) by itself has little or no effect on platelet aggregation, pretreatment of platelets with TPO augments the aggregation induced by various agonists such as ADP, thrombin, collagen, and adrenaline.

Literature References
PubMed ID Title Journal Year
8202154 Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand

de Sauvage, FJ, Hass, PE, Spencer, SD, Malloy, BE, Gurney, AL, Spencer, SA, Darbonne, WC, Henzel, WJ, Wong, SC, Kuang, WJ

Nature 1994
Participants
Orthologous Events
Authored
Reviewed
Created
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