Thrombopoietin binds the thrombopoietin receptor

Stable Identifier
R-NUL-443942
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Thrombopoietin binds the thrombopoietin receptor
Thrombopoietin (TPO) is a primary regulator of megakaryocytopoiesis. Binding of TPO to its receptor TPOR (c-Mpl) mediates pleiotropic effects on megakaryocyte development leading to significant increase in circulating platelet numbers. TPOR knockout mice show a marked reduction in bone marrow megakaryocytes and blood platelets. Although thrombopoietin (TPO) by itself has little or no effect on platelet aggregation, pretreatment of platelets with TPO augments the aggregation induced by various agonists such as ADP, thrombin, collagen, and adrenaline.
Literature References
PubMed ID Title Journal Year
8202154 Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand

Henzel, WJ, Darbonne, WC, Kuang, WJ, Hass, PE, de Sauvage, FJ, Spencer, SA, Malloy, BE, Gurney, AL, Spencer, SD, Wong, SC

Nature 1994
Participants
Input
Output
Orthologous Events
Thrombopoietin binds the thrombopoietin receptor (Homo sapiens)
Authored
Akkerman, JW  (2009-09-04)
Reviewed
Kunapuli, SP  (2010-06-07)
Created
Jupe, S  (2009-10-19)
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