Signal Peptidase (Canis) hydrolyzes the signal peptide of Preprolactin

Stable Identifier
R-NUL-445309
Type
Reaction [transition]
Species
Bos taurus
Compartment
General
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The signal peptide is cleaved by the signal peptidase complex, which contains 5 subunits. Based on homology with bacterial signal peptidases the SEC11A and SEC11C subunits are believed to be the actual proteases. The reaction shown here was demonstrated in vitro.

Literature References
PubMed ID Title Journal Year
3511473 Purification of microsomal signal peptidase as a complex

Evans, EA, Gilmore, R, Blobel, G

Proc Natl Acad Sci U S A 1986
Participants
Catalyst Activity
Catalyst Activity
Title
serine-type endopeptidase activity of Signal Peptidase Complex (Canis familiaris) [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created