NuA4 complex actetylates H2A and H4

Stable Identifier
R-NUL-4551334
Type
Reaction
Species
Gallus gallus
Compartment
Summation

The NuA4 complex contains the histone acetyltransferase (HAT) KAT5 (TIP60), a member of the MYST family. The first characterisation of a mammalian NuA4 complex identified the additonal components TRRAP, the Enhancer of Polycomb protein (EPC1), actin-like protein ACTL6A (BAF53a), which is a homolog of yeast Arp4, actin (ACTB), the SNF2-related helicase p400 (EP400) and the AAA ATPases RUVBL1 (TIP49a) and RUVBL2 (TIP49b) (Ikura et al. 2000). Subsequently further copmponents were identified as MRGBP, MORF4L1 (MRG15), MORF4L2 (MRGX), (Cai et al. 2003), BRD8, DMAP1, ING3, MEAF6, YEATS4 (Doyon et al. 2004) and VPS72 (YL1) (Cai et al. 2005).

Literature References
PubMed ID Title Journal Year
10966108 Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis

Ikura, T, Ogryzko, VV, Grigoriev, M, Groisman, R, Wang, J, Horikoshi, M, Scully, R, Qin, J, Nakatani, Y

Cell 2000
Participants
Catalyst Activity
Catalyst Activity
Title
histone acetyltransferase activity of NuA4 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed