DVL binds Ccdc88c

Stable Identifier
Reaction [binding]
Homo sapiens
SVG |   | PPTX  | SBGN
DVL binds Ccdc88c

Ccdc88c was identified as Dapple in a screen of mouse brain cDNAs for DVL1 interacting proteins (Oshita et al, 2003). Ccdc88c binds to the PDZ domain of DVL through the three amino acids Gly-Cys-Val at the C-terminus, and this interaction negatively regulates canonical WNT signaling (Oshita et al, 2003; Ekici et al, 2010).

Literature References
PubMed ID Title Journal Year
21031079 Disturbed Wnt Signalling due to a Mutation in CCDC88C Causes an Autosomal Recessive Non-Syndromic Hydrocephalus with Medial Diverticulum

Ekici, AB, Hilfinger, D, Jatzwauk, M, Thiel, CT, Wenzel, D, Lorenz, I, Boltshauser, E, Goecke, TW, Staatz, G, Morris-Rosendahl, DJ, Sticht, H, Hehr, U, Reis, A, Rauch, A

Mol Syndromol 2010
14750955 Identification and characterization of a novel Dvl-binding protein that suppresses Wnt signalling pathway

Oshita, A, Kishida, S, Kobayashi, H, Michiue, T, Asahara, T, Asashima, M, Kikuchi, A

Genes Cells 2003
Orthologous Events
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