SCF(beta-TrCP) ubiquitinates p-Gli2

Stable Identifier
R-NUL-5610711
Type
Reaction [transition]
Species
Homo sapiens
Compartment
General
SVG |   | PPTX  | SBGN
SCF(beta-TrCP) ubiquitinates p-Gli2

mGli2 is polyubiquitinated when overexpressed in HEK293 cells with myc-ubiquitin, and is degraded in a phosphorylation-dependent manner by beta TrCP. beta TrCP interacts directly with phosphorylated Gli2 as assessed by co-precipitation from HEK293 cell lysates and by in vitro binding assays (Pan et al, 2006).

Literature References
PubMed ID Title Journal Year
16611981 Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

Pan, Y, Bai, CB, Joyner, AL, Wang, B

Mol. Cell. Biol. 2006
Participants
Catalyst Activity

ubiquitin-protein transferase activity of Btrc,Fbxw11 [cytosol]

Orthologous Events
Authored
Reviewed
Created
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