GSK3 phosphorylates p-Gli2

Stable Identifier
R-NUL-5610714
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
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GSK3 phosphorylates p-Gli2

PKA-phosphorylated Gli2 from mouse cells is further phosphorylated in vitro by rabbit Gsk3b at three or more serine residues. This phosphorylation is required for Gli2 processing and degradation by the proteasome (Pan et al, 2006).

Literature References
PubMed ID Title Journal Year
16611981 Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

Pan, Y, Bai, CB, Joyner, AL, Wang, B

Mol. Cell. Biol. 2006
Participants
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of Gsk3b [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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