Reactome | Mouse JAK2 binds human common beta chain

Mouse JAK2 binds human common beta chain

Stable Identifier

R-NUL-879922

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

General

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Mouse JAK2 binds human common beta chain

JAK2 associates with IL3 receptor beta chain (IL3RB) better known as the cytokine recetpor common beta chain (Bc). This association was not found to be dependent upon, or influenced by, the presence of GM-CSF or the GM-CSF receptor alpha chain, suggesting that JAK2 and Bc may be constitutively associated (Quelle et al. 1994).

Literature References

PubMed ID	Title	Journal	Year
8007942	JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region Witthuhn, BA, Miyajima, A, Sato, N, Quelle, FW, Inhorn, RC, Ihle, JN, Griffin, JD, Eder, M	Mol Cell Biol	1994
7775438	The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor beta c chain Wagner, F, Kraft, AS, Frank, SJ, Zhao, Y	J Biol Chem	1995

Participants

Input

Output

IL3RB:Jak2 [plasma membrane] (Homo sapiens)

Orthologous Events

The common beta chain IL3RB binds JAK2 (Homo sapiens)

Authored

Ray, KP (2010-05-17)

Reviewed

Hercus, TR (2010-09-06)

Lopez, AF (2010-09-06)

Created

Jupe, S (2010-06-25)

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