RUNX1 recruits KMT2A to the Spi1 gene

Stable Identifier
R-NUL-8865513
Type
Reaction [binding]
Species
Homo sapiens
Compartment
General
SVG |   | PPTX  | SBGN
RUNX1 recruits KMT2A to the Spi1 gene

Recombinant human RUNX1 and KMT2A bind to mouse Spi1 (PU.1) gene. Endogenous mouse Cbfb is required for this interaction (Huang et al. 2011).

Literature References
PubMed ID Title Journal Year
22012064 The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations

Huang, G, Zhao, X, Wang, L, Elf, S, Xu, H, Zhao, X, Sashida, G, Zhang, Y, Liu, Y, Lee, J, Menendez, S, Yang, Y, Yan, X, Zhang, P, Tenen, DG, Osato, M, Hsieh, JJ, Nimer, SD

Blood 2011
Participants
Orthologous Events
Authored
Reviewed
Created