KTM2A trimethylates nucleosomes at the Spi1 gene locus producing H3K4Me3 mark

Stable Identifier
R-NUL-8865525
Type
Reaction [transition]
Species
Homo sapiens
Compartment
General
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KTM2A trimethylates nucleosomes at the Spi1 gene locus producing H3K4Me3 mark

Recombinant human KMT2A histone methyltransferase, in the presence of recombinant human RUNX1 and endogenous mouse Cbfb, trimethylates histone H3 subunit of nucleosomes associated with the Spi1 (PU.1) gene promoter and upstream regulatory element, producing the H3K4Me3 mark (Huang et al. 2011).

Literature References
PubMed ID Title Journal Year
22012064 The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations

Huang, G, Zhao, X, Wang, L, Elf, S, Xu, H, Zhao, X, Sashida, G, Zhang, Y, Liu, Y, Lee, J, Menendez, S, Yang, Y, Yan, X, Zhang, P, Tenen, DG, Osato, M, Hsieh, JJ, Nimer, SD

Blood 2011
Participants
Catalyst Activity
Catalyst Activity
Title
histone methyltransferase activity (H3-K4 specific) of RUNX1:Cbfb:KMT2A:Spi1 gene:Nucleosome [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created