Spi1 gene transcription is stimulated by RUNX1:Cbfb:KMT2A

Stable Identifier
R-NUL-8865529
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
General
SVG |   | PPTX  | SBGN
Spi1 gene transcription is stimulated by RUNX1:Cbfb:KMT2A

The complex of recombinant human RUNX1 and KMT2A (MLL), in the presence of endogenous mouse Cbfb, directly stimulates mouse Spi1 (PU.1) gene transcription (Huang et al. 2011).

Literature References
PubMed ID Title Journal Year
22012064 The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations

Huang, G, Zhao, X, Wang, L, Elf, S, Xu, H, Zhao, X, Sashida, G, Zhang, Y, Liu, Y, Lee, J, Menendez, S, Yang, Y, Yan, X, Zhang, P, Tenen, DG, Osato, M, Hsieh, JJ, Nimer, SD

Blood 2011
Participants
This event is regulated
Orthologous Events
Authored
Reviewed
Created