IL12RB2 binds Jak2

Stable Identifier
R-NUL-8950050
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
Interleukin-12 receptor subunit beta 2 binds Tyrosin kinase Jak2
General
SVG |   | PPTX  | SBGN
IL12RB2 binds Jak2

This reaction was inferred from the corresponding reaction "IL12RB2 binds Jak2" in species Homo sapiens. Murine Tyrosine protein kinase Jak2 (JAK2) directly associates with the intracellular domain of the human Interleukin 12 receptor subunit beta 2 (IL12RB2) . Interleukin 12 receptor subunit beta 1 (IL12RB1) and Non receptor tyrosine protein kinase TYK2 (TYK2) are not required ((Zou et al 1997, Floss et al. 2016, Yamamoto et al. 1999).

Literature References
PubMed ID Title Journal Year
10198225 Physical interaction between interleukin-12 receptor beta 2 subunit and Jak2 tyrosine kinase: Jak2 associates with cytoplasmic membrane-proximal region of interleukin-12 receptor beta 2 via amino-terminus

Yamamoto, K, Shibata, F, Miura, O, Kamiyama, R, Hirosawa, S, Miyasaka, N

Biochem Biophys Res Commun 1999
9001223 A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses

Kohlhuber, F, Rogers, NC, Watling, D, Feng, J, Guschin, D, Briscoe, J, Witthuhn, BA, Kotenko, SV, Pestka, S, Stark, GR, Ihle, JN, Kerr, IM

Mol. Cell. Biol. 1997
Participants
Orthologous Events
Authored
Reviewed
Created