Gz(rat):PKC(cow) dissociates to give phosphorylated G alpha (z)

Stable Identifier
R-NUL-8982712
Type
Reaction [dissociation]
Species
Bos taurus
Compartment
General
SVG |   | PPTX  | SBGN
Gz(rat):PKC(cow) dissociates to give phosphorylated G alpha (z)

G alpha z (Lounsbury et al. 1991) and G alpha 12 (Kozasa & Gilman, 1996) are excellent in vitro substrates for all three subtypes of protein kinase C (PKC). Activation of PKC in intact platelets by agents such as thrombin, thromboxane A2 (TXA2) analogues and phorbol esters leads to rapid and near-stoichiometric phosphorylation of G alpha z (Carlson et al. 1989). PKC can bind to G alpha z and facilitate phosphorylation at Ser-27 (Lounsbury et al. 1993). Subsequently, phosphorylated G alpha z dissociates from the complex. This phosphorylation blocks the interaction of G alpha z with Gbeta:gamma suggesting that it is a regulatory mechanism for attenuating signalling by preventing subunit reassociation.

Literature References
PubMed ID Title Journal Year
1939224 Phosphorylation of Gz in human platelets. Selectivity and site of modification

Lounsbury, KM, Casey, PJ, Brass, LF, Manning, DR

J Biol Chem 1991
Participants
Orthologous Events
Authored
Reviewed
Created
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