Stat3 binds IL7R:TSLP:CRLF2

Stable Identifier
R-NUL-8982998
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
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Stat3 binds IL7R:TSLP:CRLF2

The receptor for Thymic stromal lymphopoietin (TSLP) consists of Cytokine receptor-like factor 2 (CRLF2, TSLPR) and Interleukin-7 receptor subunit alpha (IL7R). Following binding of TSLP Signal transducer and activator of transcription 5A or 5B (STAT5A and STAT5B, or as a brief STAT5) and Signal transducer and activator of transcription 3 (STAT3) are phosphorylated (in Ba/F3 cell line).
Phosphorylation of STAT5 and STAT3 by human TSLP has only been detected on cells expressing both receptors IL7R and TSLPR (Reche et al.2001).
This is a black box event since there are no experimental details confirming binding of STAT3 and STAT5 to the receptor complex.

Literature References
PubMed ID Title Journal Year
11418668 Human thymic stromal lymphopoietin preferentially stimulates myeloid cells

Reche, PA, Soumelis, V, Gorman, DM, Clifford, T, Liu, MR, Travis, M, Zurawski, SM, Johnston, J, Liu, YJ, Spits, H, de Waal Malefyt, R, Kastelein, RA, Bazan, JF

J. Immunol. 2001
Participants
Orthologous Events
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