GSK3B phosphorylates Runx2

Stable Identifier
R-NUL-9008636
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
GSK3B phosphorylates Runx2
Recombinant human GSK3B phosphorylates recombinant mouse Runx2 on three serine residues in an evolutionarily conserved motif SPPWSYDQS (Kugimiya et al. 2007).
Literature References
PubMed ID Title Journal Year
17786208 GSK-3beta controls osteogenesis through regulating Runx2 activity

Woodgett, JR, Kawamura, N, Ohba, S, Kawaguchi, H, Kugimiya, F, Chung, UI, Nakamura, K, Chikuda, H, Azuma, Y, Hirata, M

PLoS ONE 2007
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of Runx2:GSK3B [nucleoplasm]

Physical Entity
Runx2:GSK3B [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
GSK3B phosphorylates RUNX2 (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-06-12)
Reviewed
Ducy, P  (2017-08-04)
Created
Orlic-Milacic, M  (2017-06-12)
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