Hes1 gene expression is stimulated by Notch3

Stable Identifier
R-NUL-9013683
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Hes1 gene expression is stimulated by Notch3
A recombinant mouse Notch3 intracellular domain (NICD3) positively regulates transcription from the mouse Hes1 gene promoter (Shimizu et al. 2002). Mouse NICD3, in complex with human RPBJ and MAML (MAML1, MAML2 or MAML3) was shown to directly bind to the mouse Hes1 promoter (Lin et al. 2002).
Literature References
PubMed ID Title Journal Year
11866432 Functional diversity among Notch1, Notch2, and Notch3 receptors

Shimizu, K, Hirai, H, Kumano, K, Hamada, Y, Saito, T, Chiba, S

Biochem Biophys Res Commun 2002
12386158 Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling

Oyama, T, Nagase, T, Lin, SE, Kitagawa, M, Harigaya, K

J. Biol. Chem. 2002
Participants
Input
Output
This event is regulated
Positively by
Regulator
Notch3 coactivator complex:Hes1 gene [nucleoplasm] (Homo sapiens)
Active Unit
Notch3 coactivator complex [nucleoplasm]
Orthologous Events
HES1 gene expression is stimulated by NOTCH3 and STAT1 (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-09-20)
Reviewed
Haw, R  (2017-10-30)
Created
Orlic-Milacic, M  (2017-07-25)
Cite Us!