Reactome | Pcsk1 (rat) cleaves human proinsulin to yield Insulin(25-56) and Insulin(57-110)

Pcsk1 (rat) cleaves human proinsulin to yield Insulin(25-56) and Insulin(57-110)

Stable Identifier

R-NUL-9023165

Type

Reaction [transition]

Species

Homo sapiens

Compartment

secretory granule lumen

ReviewStatus

5/5

General

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SVG | | PPTX | SBGN

Pcsk1 (rat) cleaves human proinsulin to yield Insulin(25-56) and Insulin(57-110)

Rat Pcsk1 cleaves C-terminal to arginine-56 in human proinsulin to yield the B chain (plus two C-terminal arginine residues) and a peptide containing the C-peptide and the A chain (Davidson et al. 1988, Rhodes et al. 1992).

Literature References

PubMed ID	Title	Journal	Year
3283564	Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases Davidson, HW, Rhodes, CJ, Hutton, JC	Nature	1988
1429623	Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase. Implication of a favored route for prohormone processing Rhodes, CJ, Shoelson, SE, Lincoln, B	J. Biol. Chem.	1992

Participants

Input

Output

6x2xHC-INS(25-56):4xHC-INS(57-110):2xZn2+:1xCa2+ [secretory granule lumen] (Homo sapiens)

Catalyst Activity

serine-type endopeptidase activity of Pcsk1:Ca2+ [secretory granule lumen]

Physical Entity

Pcsk1:Ca2+ [secretory granule lumen] (Rattus norvegicus)

Activity

serine-type endopeptidase activity (GO:0004252)

Orthologous Events

PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110) (Homo sapiens)

Authored

May, B (2017-09-25)

Reviewed

Gillespie, ME (2008-12-02)

D'Eustachio, P (2008-12-02)

Matthews, L (2008-12-02)

Created

May, B (2017-09-27)

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