Reactome | Pcsk2 (rat) cleaves human Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89))

Pcsk2 (rat) cleaves human Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89))

Stable Identifier

R-NUL-9023180

Type

Reaction [transition]

Species

Homo sapiens

Compartment

secretory granule lumen

ReviewStatus

5/5

General

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Pcsk2 (rat) cleaves human Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89))

Rat Pcsk2 (Prohormone Convertase 2) cleaves C-terminal to arginine-89 between the C-peptide and the A-chain (INS 90-110) of human proinsulin (Davidson et al. 1988, Rhodes et al. 1992, Bailyes et al. 1995).

Literature References

PubMed ID	Title	Journal	Year
7626024	Differences between the catalytic properties of recombinant human PC2 and endogenous rat PC2 Usac, EF, Arden, SD, Shennan, KI, Bailyes, EM, Docherty, K, Hutton, JC, Guest, PC	Biochem J	1995
3283564	Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic beta cell via two distinct site-specific endopeptidases Davidson, HW, Rhodes, CJ, Hutton, JC	Nature	1988
1429623	Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase. Implication of a favored route for prohormone processing Rhodes, CJ, Shoelson, SE, Lincoln, B	J. Biol. Chem.	1992

Participants

Input

Output

Catalyst Activity

serine-type endopeptidase activity of Pcsk2 [secretory granule lumen]

Physical Entity

Pcsk2 [secretory granule lumen] (Rattus norvegicus)

Activity

serine-type endopeptidase activity (GO:0004252)

Orthologous Events

PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89)) (Homo sapiens)

Authored

May, B (2017-09-25)

Reviewed

Gillespie, ME (2008-12-02)

D'Eustachio, P (2008-12-02)

Matthews, L (2008-12-02)

Created

May, B (2017-09-27)

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