NTF4-bound Ntrk2 dimers trans-autophosphorylate

Stable Identifier
R-NUL-9030427
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
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PNG
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 | PPTX  | SBGN
NTF4-bound Ntrk2 dimers trans-autophosphorylate
A recombinant human NTF4 (NT-4) induces trans-autophosphorylation of mouse Ntrk2 (TrkB) tyrosine residue Y515 (mouse Y515 corresponds to Y516 of human NTRK2). As the electrophoretic migration pattern of Ntrk2 phosphorylated in response to NTF4 is indistinguishable from the electrophoretic migration pattern of Ntrk2 phosphorylated in response to BDNF, and identical downstream effectors are activated, it is assumed that NTF4 induces phosphorylation of Ntrk2 on five evolutionarily conserved tyrosine residues in the cytoplasmic tail of Ntrk2: Y515, Y701, Y705, Y706 and Y816 (corresond to human NTRK2 residues Y516, Y702, Y706, Y707 and Y817) (Minichiello et al. 1998).
Literature References
PubMed ID Title Journal Year
9728915 Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses

Stucky, CL, Casagranda, F, Postigo, A, Tatche, RS, Klein, R, Davies, AM, Lewin, GR, Minichiello, L

Neuron 1998
Participants
Input
Output
Catalyst Activity

protein tyrosine kinase activity of NTF4:Ntrk2 homodimer [plasma membrane]

Physical Entity
NTF4:Ntrk2 homodimer [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
NTF4-bound NTRK2 dimers trans-autophosphorylate (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Castrén, E  (2018-02-13)
Antila, H  (2018-02-13)
Created
Orlic-Milacic, M  (2017-11-28)
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